The Plant Pathology Journal 2002;18(1):18-22.
Published online February 28, 2002.
Antiviral, Antimicrobial, and Cytotoxic Properties of Peptavirins A and B Produces by Apiocrea sp. 14T
Woon Hyun Yeo, Bong Sik Yun, Young Sook Kim, Sang Jun Lee, Ik Dong Yoo, Kab Sig Kim, Eun Kyung Park, Jong Chull Lee, Young Ho Kim
Two peptaibol antibiotics, peptavirins A and B, which exhibited strong inhibitory effect against Tobacco mosaic virus (TMV) infection, were isolated from steam-cooked rice culture of Apiocrea sp. 14T. The peptavirins were identified as new derivatives of chrysospermins, which are 19-mer and have been reported to be produced in a fungal isolate. The physicochemical properties of the peptavirins were mostly identical with chrysospermins A through D except for the UV absorption spectrum. The peptavirins inhibited the growths of the Grampositive bacteria tested, including the plant pathogenic bacterium, Corynebacterium lilium, and the fungus, Aspergillus niger. Peptavirin A was somewhat cytotoxic to cancer cell lines, especially K562 (leukemia) and DACC 62 (melanoma), whereas peptavirin B only exhibited slight cytotoxicity.
Key Words: antimicrobial activity, Apiocrea sp., cytotoxicity, peptavirins, peptaibol antibiotics

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